The focus of this talk will on the development of multifunctional nanocoating and nanoplexes with enhanced capabilities to interact with various biological targets (cells, biomarkers, growth factors, proteins, nucleic acids, etc.) for their application in regenerative medicine and nanomedicine. The use of layer-by-layer nanocoating on both artificial and biological templates to improve thrombogenicity, for immunocamouflage, and for delivery of osteogenic and angiogenic factors will be presented. The development of nanoplexes for immunomodulation, targeted in vivo gene delivery or as fluorescent probes for in vivo imaging will also be discussed. As a step towards the translation, the talk will include some examples of microfluidic devices for synthesis and fabrication of nanoplexes and nanosystems.

Maryam Tabrizian is James McGill Full Professor in the Department of Biomedical Engineering and the Faculty of Dental Medicine and Oral Health Sciences at McGill University. She holds a Canada Research Chair Tier I in Regenerative Medicine and Nanomedicine. She has received many prestigious awards and fellowships, including the FRQS-Chercheur National, Guggenheim Foundation, International Biomaterials Science & Engineering, ADEA Leadership Institute, Royal Society of Canada-Academy of Sciences, Canadian Academy of Health Sciences, and Canadian Academy of Engineering. Her research program is based on four main pillars: 1. Development of biomimetic materials to promote angiogenesis and osteogenesis, 2. Nanoplexes with targeting and tracking/imaging capabilities for tissue and cell imaging, 3. Real-time monitoring of molecular and cellular events at biointerfaces, and 4. Lab-on-a-chip devices for cell and bacterial detection, bioparticle synthesis and sorting. M. Tabrizian has over 300 peer-reviewed publications with close to 20000 citations. She has been Editor-in-Chief of Materials since 2011 and is the founding Editor-in-Chief of Exploration of Biomat-X, a free peer-reviewed journal for the dissemination of knowledge in global health, launched in 2022.